Publications

Publications between 2000 - present: Click for PDF.

• Sanjeewa N. Senadheera, Abraham l.Yousef, and Richard S. Givens, Photorelease of Phosphates: Mild Methods for Protecting the Phosphate Moiety 2014, Beilstein J. Org. Chem. 2014, 10, 2038-2054 (doi:10.3762/bjoc)

• Sanjeewa N. Senadheera, Anthony S. Evans, John P. Toscano, and Richard S. Givens, 2-Diazo-1-(4-hydroxyphenyl)ethanone: A Versatile Photochemical and Synthetic Reagent, Photochem. Photobiol. Sci. 2014, 13, 324-341 (DOI:10.1039/C3PP50305D)

• Solomek, Tomas; Heger, Dominik; Ngoy, Bokolombe; Givens, Richard; Klán, Petr, The Pivotal Role of Oxyallyl Diradicals in Photo-Favorskii Rearrangements: Transient Spectroscopic and Computational Studies, J. Am. Chem. Soc.,  2013 135, 15209−15215. (DOI: dx.doi.org/10.1021/ja407588p) 
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• Ngoy, B. P.; Sebej, P.;Solomek, T.; Lim, B. H.; Pastierik, T.; Park, B. S.; Givens, R. S.; Heger, D.; Klan, P.; 2-Hydroxyphenacyl ester: A water-soluble photoremovable protecting group.  Photochem. Photobiol. Sci. 2012, 11(9), 1465-1475.

 

• Kammath, V. B.; Solomek, T.; Ngoy, B. P.; Heger, D.; Klan, P.; Rubina, M.; Givens, R. S. “A photo-Favorskii Ring Contraction Reaction:  The Effect of Ring Size. J. Org. Chem. 2013, 77, 1718 - 1729 (DOI: dx.doi.org/10.1021/jo300850a).

 

• Givens, R.S., Rubina, M, and Stensrud, K.F. Stereochemically Probing the photo-Favorskii Rearrangement: A Mechanistic Investigation J. Org. Chem. (2013) 78, 1709-1717 (DOI:  dx.doi.org/10.1021/jo301640q |).

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• Kammath, V. B.; Solomek, T.; Ngoy, B. P.; Heger, D.; Klan, P.; Rubina, M.; Givens, R. S. “A photo-Favorskii Ring Contraction Reaction:  The Effect of Ring Size. J. Org. Chem. (2013), 77, 0000 (DOI: 10.1021/jo300850a).

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• Klán, P.; Šolomek, T.;  Bochet, C.; Blanc, A.; Givens, R.; Rubina, M.; V.  Popik, V.; Kostikov, V.; Wirz, J.Photoremovable Protecting Groups in Chemistry and Biology: Release Rates, Mechanisms, and Efficacy Chem. Rev. (2013), 113, 119−191. (DOI: 10.1039/c2pp05399c)
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• Givens, R.S., Rubina, M., Wirz, J., Applications of p-hydroxyphencyl (pHP) and coumarin-1-ylmehtyl photoremovable protecting groups, Photochem. Photobiol. Sci. (2012), 11, 472 - 488 DOI: 10.1039/c2pp05399c

 

• Ngoy, B. P.; Sebej, P.;Solomek, T.; Lim, B. H.; Pastierik, T.; Park, B. S.; Givens, R. S.; Heger, D.; Klan, P.; 2-Hydroxyphenacyl ester: A water-soluble photoremovable protecting group.  Photochem. Photobiol. Sci. (2012), 11(9), 1465-1475.

 

• Givens, R.S.; Stensrud, K. F.; Conrad, P.F.; Yousef; A.L.; Perera C.;Senadheera, S.N.; Heger; D.; Wirz, J.; p-Hydroxyphenacyl Photoremovable Protecting Groups: Robust Photochemistry Despite Substituent Diversity. Can. J. Chem. (2011) 89, 364-384.

 

• Kandler, K., Nguyen, T., Noh J. and Givens, R.S., An Optical Fiber-Based Uncaging System. Ch 41, 000, in “Imaging in Neuroscience: A Laboratory Manual” (F. Helmche, A. Konnerth Ed.) Cold Spring Harbor Laboratory protocols (2013) 2013, 111-118.

 

• Remeš, M.; Roithová, J.; Schröder, D.; Cope, E.; Perera, C.; Senadheera, S.N.; Stensrud, K.; Ma, C.; and Givens, R.S. Gas-phase Fragmentation of Deprotonated p-Hydroxyphenacyl Derivatives. J. Org. Chem. (2011) 76 , 2180-2186.
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• Sebej, Peter; Lim, Bum Hee; Park, Bong Ser; Givens, Richard S.; Klan, Petr. The Power of Solvent in Altering the Course of Photorearrangements. Org. Lett. (2011), 13(4), 644-647.

 

• Stensrud, K. F.; Noh, J.; Kandler, K.;Wirz, J.; Heger, D.; Givens, R. L.;. Competing Pathways in the Photo-Favorskii Rearrangement and Release of Esters: Studies on Fluorinated p-Hydroxyphenacyl-Caged GABA and Glutamate Phototriggers.Journal of Organic Chemistry, (2009), vol. 74, no. 15, pp. 5219-5227
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• Givens, R.S., Yousef, A. L.; Yang, S., Timberlake; G. T., Collagen Cross Linking Agents: Design and Development of a Multifunctional Cross Linker, Photochemistry and Photobiology, (2008), 84: 185–192.

 

• Givens, R.S.and Stensrud, K.L., a-Bromo-p-hydroxyacetophenone, Electronic Encyclopedia of Reagents for Organic Synthesis (2008) DOI: 10.1002/047084289X.rn00969

 

• Stensrud, K. F.；Adam, P. R.；La Mar, C. D.;Olive, A. J.;Lushington, G. H.；Sudharsan, R.；Shelton, N. L.；Givens, R. S.；Picking, W. L.；Picking, W. D., Deoxycholate Interacts with IpaD of Shigella flexneri in Inducing the Recruitment of IpaB to the Type III Secretion Apparatus Needle Tip, The Journal of Biological Chemistry , (2008), vol.283(no.27).

 

• Stensrud, K. F.; Heger, D.;Sebej, P.;Wirz, J.;Givens, R. S.; Fluorinated photoremovable protecting groups: the influence of fluoro substituents on the photo-Favorskii rearrangement. Photochemical & Photobiological Sciences, ( 2008), vol. 7, no. 5, pp. 614 - 624.

 

• Conrad, P. II; Chavli, R. V.; Givens, R. S. Caged substrates applied to high content screening: An introduction with an eye to the future in “High Content Screening: A Powerful Approach in Systems Cell Biology and Drug Discovery”, Methods in Molecular Biology, High Content Screening (2007) Kenneth A Giuliano, Jeffrey Haskins, and D. Lans Taylor, ed., pp. 253-265.

 

• Givens, R. S.; Lee, J.-I.; Kotala, M. Mechanistic overview of phototriggers and cage release (Ch. 2) in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules (2005) J. Wiley, and Sons, pp. 95–12(Chapter 2).

 

• Givens, R. S.; Goeldner, M. (co-editors) Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules, (2005) J. Wiley, and Sons, (monograph). (95. Reviewed in J. Am. Chem. Soc.)

 

• Givens, R. S.; Yousef, A. p-Hydroxyphenacyl: A Photoremovable Protecting Group for Caging Bioactive Substrates (Ch. Ic) in Dynamic Studies in Biology: Phototriggers, Photoswitches, and Caged Biomolecules (2005) J. Wiley, and Sons, pp. 55–75. (Chapter 1.2)

 

• Timberlake, G. T.; Yousef, A. L., Chiles, S. R.; Moses, R. A.; Givens, R. S. Bonding Corneal Tissue: Applications of photoactivated diazopyruvoyl crosslinking agent, (2005) Photochem. Photobiol., 81, 1180–1185.

 

• Zou, X.; Mosha, D.; Archibald, S.J.; McCasland, A.K.; Hassan, A. M.; Givens, R. S.; Busch, D. H. Toward the Soil Poultice and a New Separations Methodology: Rebinding of Macrocyclic Metal Complexes to Molecularly Imprinted Polymers Specifically Templated via Non-covalent Interactions, (2005) Journal of Coordination Chemistry, 58, 21–39.

 

• Sul, J-Y; Orosz, G.; Givens, R. S.; Haydon, P. G. Astrocytic Circuits in the Hippocampus, (2004) Neuron Glia Biology, 1, 3–10. (94. Cited in Scientific American in March, 2004.)

 

• Zuo, X.; Mosha, D.; Hassan, M. M.; Givens, R. S.; Busch, D. H. A novel methodology for metal ion separation based on molecularly imprinting. (2004) Preprints of Extended Abstracts presented at the ACS National Meeting, American Chemical Society, Division of Environmental Chemistry, 44(1), 471–473.

 

• Givens, R. S.; Conrad, P. G. II; Yousef, A. L.; Lee, J.-I., Photoremovable Protecting Groups in CRC Handbook of Organic Photochemistry and Photobiology, (2003) 2nd Edition, W. M. Horspool, ed., Ch. 69, pp 69.1–69.46.

 

• Givens, R. S.; Lee, J.-I. The p-Hydroxyphenacyl Photoremovable Protecting Group, (2003) J.>Photoscience, 10, 37–48.

 

• Zou, X; Archibald, S.J.; Hassan, A. M., Givens, R. S.; McCasland, A. K.; Busch, D. H. Toward the soil poultice and a new separation methodology: Rebinding of macrocycle metal complexes to molecularly imprinted polymers specifically templated via hydrogen bonding, Journal of Coordination Chemistry  2005, 58, 21–39.
• Timberlake, G. T.; Reddy, G. K.; Steno-Bittel, L.; Weber, J. J. W.; Amslinger, S.; Givens, R. S. Photoactivated coumaryl-diazopyruvate fluorescent label for amine functional groups of tissues containing type I collagen. (2002) Photochem. Photobiol., 76(5), 473–479.

 

• Zou, K.; Cheley, S.; Givens, R. S.; Bayley, H. Catalytic subunit of protein kinase A caged at the activating phosphothreonine, (2002) J. Amer. Chem. Soc., 124, 8220–8229.

 

• Zou, K.; Miller, T. W.; Givens, R. S.; Bayley, H. Caged Thiophphotyrosine Peptides, (2001) Angew. Chem. Int. Ed, 40, 3049–3051.

 

• Conrad II, P. G.; Givens, R. S.; Hellrung, B.; Rajesh, C. S., Ramseier, M.; Wirz, J. p-Hydroxyphenacyl Phototriggers: The Reactive Excited State of Phosphate Photorelease, (2000) J. Am. Chem. Soc., 122, 9346–9347.

 

• Conrad II, P. G.; Givens, R. S.; Weber, J. F. W.; Kandler, K. New Phototriggers 10: Extending the p,p* Absorption to Release Peptides in Biological Media, (2000) Org. Lett. 2, 1545–1547.
• Geibel, S.; Barth, A.; Amslinger, S.; Jung, A. H.; Burzik, C.; Clarke, R. J.; Givens, R.; Fendler, K. P3-[2-(4-hydroxyphenyl)-2-oxo]ethyl ATP for the rapid activation of the Na+,K+-ATPase. (2000) Biophys. J., 79(3), 1346–1357

 

• Givens, R. S.; Weber, J. F. W.; Conrad II, P. G.; Orosz, G.; Donahue, S. L.; Thayer, S. A New Phototriggers 9: p-Hydroxyphenacyl as a C-Terminus Photoremovable Protecting Group for Oligopeptides, (2000) J. Am. Chem. Soc.,122, 2687–2697.

 

• Rajesh, C. S.; Givens, R.; Wirz, J. Kinetics and Mechanism of Phosphate Photorelease from Benzoin Diethyl Phosphate: Evidence for Adiabatic Fission to an α-Keto Cation in the Triplet State, (2000) J. Am. Chem. Soc., 122, 611–618.

 

• Rajesh, C. S.; Givens, R.; Wirz, J. Kinetics and Mechanism of Phosphate Photorelease from Benzoin Diethyl Phosphate: Evidence for Adiabatic Fission to an α-Keto Cation in the Triplet State, (2000) J. Am. Chem. Soc., 122, 611–618.

Patents:

• Givens, Richard S.; Ma, Chi Cheng; Busch, Daryle H.; Subramaniam, Bala; Rajagopalan, Bhuma. 149:56035  AN 2008:706812   Cobalt-catalyzed oxidations in volumetrically expanded liquids by compressed gases.    U.S. Pat.   (2012), 13pp.  CODEN: USXXCO  US  2008139841  A1  20080612  CAN 149:56035  AN 2008:706812    CAPLUS; PatentFiling Date:  November 2, 2007 Granted: February 14, 2012. SMH Reference No.:  506274-0049. KU Reference No.:  2007FY07

 

• Richard S. Givens, George T. Timberlake, Peter G. Conrad II, Photo-triggerable, Collagen Crosslinking Compounds for Wound Closure. Patent # 6,783,539 (US) August 31, 2004.

 

• R. S. Givens, R. G. Carlson, K. Srinivasachar and O. S. Wong, T. Higuchi, Substi­tuted 2,3-Naphthalenedicarboxaldehydes. U.S. Patent. Issued: Feb. 2, 1988 Patent No. 4,723,022 (US; Also Australian, New Zealand, European Convention).

 

• B. Matuszewski, R. S. Givens, R. G. Carlson, T. Kawasaki and O. S. Wong, Chemiluminescence Method For Assaying Compounds Containing Primary Amino Groups Using 1-Cyano-2-Substituted Benz[f]-or Naphth[f]isoindole Fluorescers U. S. Issued: July 19, 1988. Patent No. 4,758,520, serial no. 837,671 (US; also Australia, Canada, New Zealand).